Postdoctoral Researcher in Neuroimaging and Integrative Brain Analyses

University of Pennsylvania · Department of Neuroscience, Perelman School of Medicine · Platt Lab

Open until filled Postdoc
Apply on Interfolio

The role

Leads the project's brain-aging work: building pipelines for 7T ex vivo MRI of archived macaque brain hemispheres across the adult lifespan, and connecting what the scans show to RNA-seq and DNA methylation from the same brains. The results feed the consortium's multidomain ageotype models.

What the work covers

  • Ex vivo 7T MRI protocols, quality control and segmentation (FreeSurfer, ANTs, FSL or similar)
  • Atlas registration (D99, INIA19) and regional measures of brain aging
  • Brain RNA-seq and DNA methylation, including epigenetic clocks
  • Linking brain measures to physiology, behaviour, social data and survival
  • Reproducible pipelines (Snakemake or Nextflow), and data deposits with CayoHub

What they're looking for

  • PhD in neuroscience, neuroimaging, genomics, computational biology or a related field
  • Structural MRI analysis: volumetric segmentation and morphometry
  • RNA-seq or DNA methylation analysis
  • Scripting and statistics in Python, R, Bash or similar
  • Peer-reviewed publications

How to apply

Through Interfolio, send:

  • Cover letter, including your desired start date
  • CV with publications
  • Three references